Mesotherapy: what it is and where it is used

Published: 10 August 2026 · Medically reviewed by: Op. Dr. Murat Alpay

Mesotherapy explained: how the technique works, what it is used for, how many sessions are typically needed, its side effects and who it is not suitable for.

Mesotherapy is a non-surgical treatment in which very small doses of an active substance are injected directly into the skin (intradermally) or just beneath it. Because it is applied straight to the area concerned, lower doses are sufficient than with medication acting on the whole body.

What mesotherapy is

Mesotherapy (intradermal therapy) was first developed in 1952 by the French doctor Michel Pistor, and in 1987 it was recognised by the French Academy of Medicine as a formal medical field. The injected substances form a small reservoir in the dermis or subcutaneous tissue, from which they reach the target tissue slowly through the local circulation. The multiple small punctures made during the procedure also trigger the tissue's own renewal mechanisms.

Where and why it is used

  • Skin renewal: applied to the face, neck, décolletage and backs of the hands to support the skin's moisture, brightness and firmness.
  • Hair loss: used to support circulation in the scalp and improve hair quality.
  • Cellulite and localised fat: may be applied to the legs, hips and abdomen to support local appearance.
  • Stretch marks and scars: may be used to support the tissue repair process.

How it is done, and how many sessions

The number of sessions and the intervals between them depend on the aim, the substance used and the person's skin. It usually begins with a series of sessions a few weeks apart, followed by maintenance sessions at longer intervals. The protocol right for you is decided by your doctor after assessment.

Side effects and risks

Mesotherapy is generally well tolerated, but some temporary effects can occur: mild redness at the site, itching, a burning sensation, small bruises and slight swelling. If the depth or quantity of the injection is not judged correctly, nodules (firm lumps) or damage to the skin can occur. There is also a possibility of allergic reactions to the substances used, and a risk of infection where sterile technique is not followed.

Who it is not suitable for

  • women who are pregnant or breastfeeding
  • those with a known allergy to the substances to be used
  • those with a bleeding disorder, or taking blood-thinning treatment
  • those with an autoimmune disease, uncontrolled diabetes or a history of cancer
  • those with an active skin infection or inflammatory skin condition in the treatment area
  • those with a history of epilepsy
  • those prone to keloid or hypertrophic (thickened) scarring

This list does not cover every situation; whether it is suitable for you is decided by your doctor after examination.

Frequently asked questions

Is mesotherapy painful?

There may be a mild stinging or burning from the needling during the procedure; it is generally tolerated comfortably.

Is the effect permanent?

No. Maintenance sessions at set intervals are needed to preserve the results.

Can it be done for everyone?

No. Mesotherapy is not used in the situations listed above; suitability is assessed by medical examination.

See also mesotherapy.